Everything on this site is supplied as a laboratory reference material for in-vitro research use only. Nothing here is a medicine, and nothing here is licensed for administration to humans or animals.
By entering you confirm you are aged 18 or over, that you are acquiring these materials for legitimate research purposes, and that you will not administer them to any person or animal.
PT-141
What is PT-141?
PT-141, also known as Bremelanotide, is a synthetic cyclic heptapeptide and an analogue of alpha-melanocyte-stimulating hormone (α-MSH). It was developed from Melanotan II and acts as an agonist at melanocortin receptors, mainly MC3R and MC4R.
Unlike most peptides that act on peripheral tissue, PT-141 is studied for its action on melanocortin pathways in the brain, particularly the hypothalamus. Researchers use it to investigate how the central melanocortin system regulates behaviour, signalling and autonomic responses.
PT-141 vs Melanotan II: both are cyclic melanocortin peptides, and PT-141 is a metabolite of Melanotan II. The key research difference is that PT-141 has much lower activity at the MC1 receptor, which governs melanin production, so it is used where researchers want to study MC3R/MC4R signalling without the pigmentation effects associated with Melanotan II.
How to reconstitute PT-141: the 10mg vial is supplied as a lyophilised powder. Reconstituted with 2ml of bacteriostatic water it gives 5mg/ml. Add the water slowly down the side of the vial and swirl gently rather than shaking.
Each batch is tested for HPLC purity and mass-spec identity, and the certificate of analysis for your exact batch is downloadable from this page before you order. When buying PT-141 from any UK supplier, check that a batch-specific COA is available.
Supplied for laboratory research use only. Not for human or veterinary use.
PT-141 reconstitution reference
Reconstitute with bacteriostatic water. The table shows the concentration and syringe volume produced by common dilutions of a 10mg vial, for reference when preparing research stock solutions.
Storage & handling
Frequently asked questions
What is PT-141?
PT-141 (Bremelanotide) is a synthetic cyclic peptide that acts on melanocortin receptors, mainly MC3R and MC4R. It is studied in laboratory research on central melanocortin signalling in the brain.
Is PT-141 the same as Bremelanotide?
Yes. PT-141 is the original research code for Bremelanotide. Both names describe the same cyclic heptapeptide sequence.
What is the difference between PT-141 and Melanotan II?
PT-141 is a metabolite of Melanotan II. Both act on melanocortin receptors, but PT-141 has much lower MC1 receptor activity, so researchers use it to study MC3R/MC4R signalling without the pigmentation effects linked to Melanotan II.
