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5-Amino-1MQ 50mg
What is 5-Amino-1MQ 50mg?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small, membrane-permeable molecule that selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in fat tissue and the liver.
NNMT uses S-adenosylmethionine (SAM) to methylate nicotinamide, a precursor of NAD+. In laboratory models, raised NNMT activity has been linked to lower NAD+ and SAM levels in adipocytes. Researchers use 5-Amino-1MQ to study what happens when this pathway is blocked, including effects on cellular energy expenditure, lipid storage and fat cell size in diet-induced obesity models.
5-Amino-1MQ vs NAD+: NAD+ is the coenzyme itself, while 5-Amino-1MQ acts upstream by blocking an enzyme that diverts nicotinamide away from NAD+ production. The two are often studied together in metabolic research, along with MOTS-c and SS-31.
5-Amino-1MQ is not a peptide. It is a quinolinium small molecule, stocked by peptide suppliers because it is researched alongside metabolic peptides.
How to reconstitute 5-Amino-1MQ: the 50mg vial is supplied as a lyophilised powder. Reconstituted with 5ml of bacteriostatic water it gives 10mg/ml. Add the water slowly down the side of the vial and swirl gently until fully dissolved.
Each batch is tested for HPLC purity and identity, and the certificate of analysis for your exact batch is downloadable from this page before you order. When buying 5-Amino-1MQ from any UK supplier, check that a batch-specific COA is available.
Supplied for laboratory research use only. Not for human or veterinary use.
5-Amino-1MQ 50mg reconstitution reference
Reconstitute with bacteriostatic water. The table shows the concentration and syringe volume produced by common dilutions of a 10mg vial, for reference when preparing research stock solutions.
Storage & handling
Frequently asked questions
What is 5-Amino-1MQ?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of the enzyme NNMT. It is studied in laboratory models of fat cell metabolism, energy expenditure and cellular NAD+ levels.
Is 5-Amino-1MQ a peptide?
No. 5-Amino-1MQ is a quinolinium small molecule, not a chain of amino acids. Peptide suppliers stock it because it is researched alongside metabolic peptides such as MOTS-c and SS-31.
What is NNMT?
Nicotinamide N-methyltransferase (NNMT) is an enzyme found mainly in fat tissue and the liver. It methylates nicotinamide using SAM, which researchers link to lower NAD+ and SAM availability in adipocytes.
