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SS-31
What is SS-31?
SS-31, also known as Elamipretide, is a synthetic tetrapeptide (D-Arg-Dmt-Lys-Phe-NH2) from the Szeto-Schiller family of mitochondria-targeted peptides. Its alternating aromatic and positively charged residues let it cross cell membranes and concentrate in the inner mitochondrial membrane.
There it binds cardiolipin, a phospholipid that holds the electron transport chain together. Researchers study SS-31 in laboratory models of mitochondrial dysfunction, oxidative stress and cellular energy production, where it is used to investigate how stabilising cardiolipin affects ATP output and reactive oxygen species.
SS-31 vs MOTS-c: both are studied in mitochondrial research but work differently. SS-31 acts on the mitochondrial membrane itself, while MOTS-c is a mitochondrial-derived peptide studied for its signalling role in metabolic regulation. Researchers often compare the two, and also use them alongside NAD+.
How to reconstitute SS-31: SS-31 is supplied as a lyophilised powder. A 10mg vial reconstituted with 2ml of bacteriostatic water gives 5mg/ml. Add the water slowly down the side of the vial and swirl gently rather than shaking.
Available in 10mg and 50mg vials. Each batch is tested for HPLC purity and mass-spec identity, and the certificate of analysis for your exact batch is downloadable from this page before you order. When buying SS-31 from any UK supplier, check that a batch-specific COA is available.
Supplied for laboratory research use only. Not for human or veterinary use.
SS-31 reconstitution reference
Reconstitute with bacteriostatic water. The table shows the concentration and syringe volume produced by common dilutions of a 10mg vial, for reference when preparing research stock solutions.
Storage & handling
Frequently asked questions
What is SS-31?
SS-31 (Elamipretide) is a synthetic tetrapeptide that targets the inner mitochondrial membrane, where it binds cardiolipin. It is studied in laboratory models of mitochondrial function, oxidative stress and cellular energy production.
Is SS-31 the same as Elamipretide?
Yes. SS-31 is the original research code for Elamipretide. It has also been referred to as MTP-131 and Bendavia. All names describe the same D-Arg-Dmt-Lys-Phe-NH2 sequence.
Which SS-31 vial size should I choose?
The 10mg vial suits shorter or pilot research protocols. The 30mg vial is better value for longer studies, but reconstitute only what you will use within 28 days.
